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Mediastinum
The mediastinum is a compartment located between two pleural sacs.
The borders are:
- Anterior: Sternum.
- Posterior: Vertebral column (bodies of thoracic vertebrae and intervening intervertebral discs T1-T12).
- Superior: Superior thoracic aperture.
- Inferior: Diaphragm.
- On every side: Mediastinal pleura

The mediastinum is divided into two main parts by an imaginary line that runs from the sternal angle to the T4 vertebrae:
- Superior Mediastinum – extends upwards, terminating at the superior thoracic aperture.
- Inferior Mediastinum – extends downwards, terminating at the diaphragm. The inferior mediastinum is further divided into anterior, middle and posterior.
Superior Mediastinum
Borders
- Superior – Superior thoracic aperture. An oblique plane extending from the jugular notch of the manubrium to the superior border of T1 vertebra.
- Inferior – Continuous with the inferior mediastinum, a transverse plane extending from the sternal angle to the T4-T5 intervertebral disc.
- Anterior – Manubrium of the sternum.
- Posterior – Vertebral bodies of T1-4.
- Lateral – Mediastinal pleura
Contents
- Great Vessels
- Aortic arch including all three main branches – brachiocephalic, left subclavian, left common carotid;
- Tributaries of SVC – brachiocephalic veins, left superior intercostal vein, supreme intercostal vein and azygos vein.
- Nerves
- Vagus nerve – right and left
- Phrenic nerve
- Sympathetic trunk
- Cardiac nerves
- Other structures
- Thymus
- Trachea
- Thoracic Duct
- Oesophagus
Inferior Mediastinum
Anterior Mediastinum
Borders
- Superior – Continuous with the superior mediastinum at the level of the sternal angle, T4
- Inferior – Diaphragm.
- Anterior – Body of the sternum and the transversus thoracis muscles.
- Posterior – Anterior borders of pericardium
- Lateral – Mediastinal pleura
Content (this is the largest division and contains important structures)
- Inferior portion of thymus (in infants and children)
- Fat
- Connective tissue
- Lymph nodes
- Mediastinal branch of internal thoracic vessels
- Sternopericardial ligaments
Middle Mediastinum
Borders
- Superior – Continuous with the superior mediastinum at the level of the sternal angle, T4
- Inferior – Diaphragm.
- Anterior – Anterior border of pericardium
- Posterior – Posterior border of pericardium
- Lateral – Mediastinal pleura
Contents
- Great Vessels
- Ascending aorta
- SVC
- Pulmonary trunk – branching into right and left pulmonary arteries
- Nerves
- Cardiac plexus – The sympathetic nerves are derived from T1-T4 spinal cord segments, and the vagus nerve provide parasympathetic innervation.
- Phrenic nerve – left and right
- Other structures
- Heart
- Pericardium
- Tracheal bifurcation – right and left main bronchus
Posterior Mediastinum
Borders
- Superior – Continuous with the superior mediastinum at the level of the sternal angle, T4
- Inferior – Diaphragm.
- Anterior – Posterior border of the pericardium
- Posterior – T5-T12 vertebrae.
- Lateral – Mediastinal pleura
Contents
- Thoracic aorta including – posterior intercostal, bronchial, oesophageal, and superior phrenic arteries.
- Azygous system of veins
- Thoracic duct
- Oesophagus
- Oesophageal plexus
- Sympathetic trunks